GPRC5B

G protein-coupled receptor class C group 5 member B | RAIG-2

This gene encodes a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The encoded protein may modulate insulin secretion and increased protein expression is associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Member of: DE-12 DE-12.1

Biological processes 27 terms

G protein-coupled receptor activity (GO:0004930)G protein-coupled receptor binding (GO:0001664)G protein-coupled receptor signaling pathway (GO:0007186)cell surface (GO:0009986)cell surface (GO:0009986)cell volume homeostasis (GO:0006884)cytoplasmic vesicle membrane (GO:0030659)extracellular exosome (GO:0070062)extracellular exosome (GO:0070062)extracellular exosome (GO:0070062)extracellular region (GO:0005576)intracellular signal transduction (GO:0035556)intracellular signal transduction (GO:0035556)membrane (GO:0016020)membrane raft (GO:0045121)membrane raft (GO:0045121)plasma membrane (GO:0005886)plasma membrane (GO:0005886)protein binding (GO:0005515)protein kinase activator activity (GO:0030295)protein kinase activator activity (GO:0030295)protein kinase binding (GO:0019901)protein kinase binding (GO:0019901)protein kinase binding (GO:0019901)protein kinase inhibitor activity (GO:0004860)protein tyrosine kinase binding (GO:1990782)signaling receptor complex (GO:0043235)

Expression (TPM)

TFs regulating GPRC5B 0 TFs

Transcription factors with Perturb-seq knockdown data for GPRC5B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPRC5B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to GPRC5B

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPRC5B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr16:19,555,060–19,556,522	329.4 kb	Distal (>10kb) Multiome HiCAR	1001
chr16:19,717,856–19,718,929	166.6 kb	Distal (>10kb) Multiome HiCAR	935
chr16:19,722,929–19,723,622	161.6 kb	Distal (>10kb) Multiome HiCAR	66
chr16:19,853,872–19,854,881	30.4 kb	Distal (>10kb) Multiome	59
chr16:19,882,759–19,882,979	1.9 kb	Proximal (<10kb)	33
chr16:19,883,280–19,884,526	337 bp	At TSS	233
chr16:19,884,718–19,885,614	111 bp	At TSS Multiome	352
chr16:19,886,340–19,886,562	1.5 kb	Proximal (<10kb)	547
chr16:20,073,523–20,074,238	189.0 kb	Distal (>10kb) Multiome	148
chr16:20,740,958–20,742,211	856.9 kb	Distal (>10kb) Multiome HiCAR	971

Genome Browser

Genomic view of the GPRC5B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.