Predicted to enable calcium channel activity. Involved in neuron migration and stem cell differentiation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GPM6A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPM6A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPM6A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:175,998,915–175,999,255 | 3.1 kb | Proximal (<10kb) | 64 | |
| chr4:176,000,916–176,002,700 | 94 bp | At TSS Multiome | 467 | |
| chr4:176,005,411–176,006,142 | 3.6 kb | Proximal (<10kb) Multiome | 87 | |
| chr4:176,006,260–176,006,720 | 3.9 kb | Proximal (<10kb) | 25 | |
| chr4:176,065,262–176,066,534 | 63.6 kb | Distal (>10kb) Multiome | 484 | |
| chr4:176,194,750–176,196,011 | 193.2 kb | Distal (>10kb) Multiome | 672 | |
| chr4:176,299,830–176,300,857 | 297.9 kb | Distal (>10kb) Multiome | 90 |
Genomic view of the GPM6A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.