GNA13

G protein subunit alpha 13 | G13, MGC46138

Enables G protein activity. Involved in Rho-activating G protein-coupled receptor signaling pathway. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Member of: DE-10 DE-10.3 Developmental clusters: GC1

Biological processes 41 terms

D5 dopamine receptor binding (GO:0031752)G protein activity (GO:0003925)G protein activity (GO:0003925)G protein-coupled receptor binding (GO:0001664)G protein-coupled receptor signaling pathway (GO:0007186)G-protein beta/gamma-subunit complex binding (GO:0031683)G-protein beta/gamma-subunit complex binding (GO:0031683)GTPase activity (GO:0003924)GTPase activity (GO:0003924)GTPase activity (GO:0003924)Rho protein signal transduction (GO:0007266)Rho protein signal transduction (GO:0007266)Rho-activating G protein-coupled receptor signaling pathway (GO:0160221)Rho-activating G protein-coupled receptor signaling pathway (GO:0160221)adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0007189)adenylate cyclase-modulating G protein-coupled receptor signaling pathway (GO:0007188)adenylate cyclase-modulating G protein-coupled receptor signaling pathway (GO:0007188)brush border membrane (GO:0031526)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic side of plasma membrane (GO:0009898)cytosol (GO:0005829)extracellular exosome (GO:0070062)focal adhesion (GO:0005925)guanyl nucleotide binding (GO:0019001)guanyl-nucleotide exchange factor activity (GO:0005085)heterotrimeric G-protein complex (GO:0005834)melanosome (GO:0042470)membrane (GO:0016020)nucleus (GO:0005634)nucleus (GO:0005634)plasma membrane (GO:0005886)plasma membrane (GO:0005886)postsynapse (GO:0098794)protein binding (GO:0005515)regulation of blood pressure (GO:0008217)regulation of postsynapse assembly (GO:0150052)regulation of small GTPase mediated signal transduction (GO:0051056)signal transduction (GO:0007165)signal transduction (GO:0007165)

Expression (TPM)

TFs regulating GNA13 0 TFs

Transcription factors with Perturb-seq knockdown data for GNA13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GNA13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to GNA13

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GNA13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:64,773,965–64,774,847	282.3 kb	Distal (>10kb) Multiome	481
chr17:64,776,631–64,777,384	279.7 kb	Distal (>10kb) Multiome	616
chr17:64,778,215–64,779,097	278.0 kb	Distal (>10kb) Multiome	185
chr17:64,779,868–64,781,331	276.3 kb	Distal (>10kb) Multiome	287
chr17:64,836,863–64,837,361	219.6 kb	Distal (>10kb) Multiome	286
chr17:64,918,788–64,920,342	137.2 kb	Distal (>10kb) Multiome	704
chr17:64,975,096–64,976,234	81.1 kb	Distal (>10kb) Multiome	1057
chr17:65,055,840–65,057,373	53 bp	At TSS Multiome	946
chr17:65,057,526–65,058,894	1.6 kb	Proximal (<10kb) Multiome	300
chr17:65,061,726–65,061,891	5.0 kb	Proximal (<10kb)	34
chr17:65,100,219–65,101,279	44.0 kb	Distal (>10kb) Multiome	634
chr17:65,123,077–65,123,614	66.6 kb	Distal (>10kb) Multiome	724
chr17:65,136,968–65,137,867	80.6 kb	Distal (>10kb) Multiome	573
chr17:65,294,030–65,294,715	237.7 kb	Distal (>10kb) Multiome	350

Genome Browser

Genomic view of the GNA13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.