This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides.[provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for GMPR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GMPR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GMPR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:15,662,157–15,663,390 | 575.6 kb | Distal (>10kb) Multiome HiCAR | 900 | |
| chr6:15,948,931–15,949,913 | 289.1 kb | Distal (>10kb) Multiome | 472 | |
| chr6:16,128,529–16,130,130 | 109.6 kb | Distal (>10kb) Multiome | 1070 | |
| chr6:16,174,497–16,175,068 | 63.7 kb | Distal (>10kb) Multiome | 94 | |
| chr6:16,238,170–16,238,814 | 81 bp | At TSS Multiome | 433 | |
| chr6:16,239,183–16,239,930 | 597 bp | At TSS | 347 | |
| chr6:16,244,876–16,245,160 | 6.3 kb | Proximal (<10kb) | 92 | |
| chr6:16,331,420–16,332,565 | 93.7 kb | Distal (>10kb) Multiome | 498 |
Genomic view of the GMPR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.