This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Multiple splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for GLMN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GLMN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GLMN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:92,029,331–92,030,637 | 268.8 kb | Distal (>10kb) Multiome | 471 | |
| chr1:92,079,936–92,081,084 | 218.5 kb | Distal (>10kb) Multiome | 692 | |
| chr1:92,298,519–92,299,563 | 54 bp | At TSS Multiome | 840 | |
| chr1:92,441,538–92,442,309 | 143.0 kb | Distal (>10kb) Multiome | 718 | |
| chr1:92,473,597–92,474,467 | 175.0 kb | Distal (>10kb) Multiome | 137 | |
| chr1:92,480,069–92,481,737 | 181.7 kb | Distal (>10kb) Multiome | 287 | |
| chr1:92,482,022–92,487,176 | 187.0 kb | Distal (>10kb) Multiome | 917 |
Genomic view of the GLMN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.