Enables protein homodimerization activity. Involved in positive regulation of ERK1 and ERK2 cascade; positive regulation of epithelial cell migration; and positive regulation of epithelial to mesenchymal transition. Located in Golgi membrane. Biomarker of pancreatic ductal adenocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GLIPR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GLIPR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GLIPR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:36,036,454–36,037,604 | 99.7 kb | Distal (>10kb) Multiome | 528 | |
| chr9:36,118,241–36,119,014 | 18.3 kb | Distal (>10kb) Multiome | 47 | |
| chr9:36,135,958–36,137,395 | 128 bp | At TSS Multiome | 462 | |
| chr9:36,166,123–36,166,839 | 29.9 kb | Distal (>10kb) Multiome | 515 | |
| chr9:36,188,047–36,188,562 | 51.7 kb | Distal (>10kb) Multiome | 13 | |
| chr9:36,190,463–36,191,342 | 54.1 kb | Distal (>10kb) Multiome | 863 | |
| chr9:36,257,896–36,258,893 | 121.6 kb | Distal (>10kb) Multiome | 891 | |
| chr9:36,400,210–36,402,094 | 264.3 kb | Distal (>10kb) Multiome | 864 |
Genomic view of the GLIPR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.