Enables calcium ion binding activity; heparosan-N-sulfate-glucuronate 5-epimerase activity; and protein homodimerization activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Implicated in cerebrovascular disease and hypertension. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GLCE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GLCE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GLCE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:68,875,234–68,876,172 | 284.8 kb | Distal (>10kb) Multiome | 433 | |
| chr15:68,991,545–68,992,257 | 168.8 kb | Distal (>10kb) Multiome | 290 | |
| chr15:69,059,802–69,060,199 | 100.5 kb | Distal (>10kb) Multiome HiCAR | 71 | |
| chr15:69,074,015–69,074,755 | 86.0 kb | Distal (>10kb) Multiome | 443 | |
| chr15:69,087,968–69,090,194 | 72.1 kb | Distal (>10kb) Multiome | 309 | |
| chr15:69,117,299–69,117,876 | 42.9 kb | Distal (>10kb) Multiome | 153 | |
| chr15:69,160,021–69,161,216 | 118 bp | At TSS Multiome | 783 | |
| chr15:69,161,327–69,162,026 | 744 bp | At TSS | 307 | |
| chr15:69,290,511–69,291,221 | 130.3 kb | Distal (>10kb) Multiome | 40 | |
| chr15:69,298,371–69,299,879 | 138.3 kb | Distal (>10kb) Multiome | 345 | |
| chr15:69,413,943–69,415,079 | 253.8 kb | Distal (>10kb) Multiome | 826 | |
| chr15:69,452,178–69,453,528 | 292.2 kb | Distal (>10kb) Multiome | 983 |
Genomic view of the GLCE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.