The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for GINS4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GINS4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GINS4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:41,276,067–41,276,631 | 252.8 kb | Distal (>10kb) Multiome | 97 | |
| chr8:41,308,199–41,310,004 | 219.7 kb | Distal (>10kb) Multiome | 268 | |
| chr8:41,341,689–41,343,004 | 186.9 kb | Distal (>10kb) Multiome | 138 | |
| chr8:41,360,734–41,361,748 | 168.1 kb | Distal (>10kb) Multiome | 214 | |
| chr8:41,489,933–41,491,073 | 38.7 kb | Distal (>10kb) Multiome | 716 | |
| chr8:41,528,584–41,529,537 | 118 bp | At TSS Multiome | 730 | |
| chr8:41,529,665–41,529,875 | 439 bp | At TSS | 110 | |
| chr8:41,567,337–41,567,862 | 38.2 kb | Distal (>10kb) Multiome | 108 | |
| chr8:41,577,579–41,578,739 | 48.9 kb | Distal (>10kb) Multiome | 755 | |
| chr8:41,646,199–41,646,780 | 117.2 kb | Distal (>10kb) Multiome | 132 | |
| chr8:41,653,451–41,654,479 | 124.8 kb | Distal (>10kb) Multiome | 235 | |
| chr8:41,701,707–41,702,358 | 172.7 kb | Distal (>10kb) Multiome | 481 | |
| chr8:41,766,804–41,768,073 | 238.1 kb | Distal (>10kb) Multiome | 304 | |
| chr8:41,791,812–41,792,404 | 263.0 kb | Distal (>10kb) Multiome | 574 | |
| chr8:41,818,697–41,819,374 | 289.7 kb | Distal (>10kb) Multiome | 577 | |
| chr8:41,828,115–41,829,096 | 299.3 kb | Distal (>10kb) Multiome | 805 |
Genomic view of the GINS4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.