Transcription factors with Perturb-seq knockdown data for GATA6-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GATA6-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GATA6-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:21,912,423–21,913,408 | 256.6 kb | Distal (>10kb) Multiome HiCAR | 73 | |
| chr18:21,933,673–21,935,412 | 234.7 kb | Distal (>10kb) Multiome HiCAR | 335 | |
| chr18:21,990,759–21,991,669 | 178.2 kb | Distal (>10kb) Multiome HiCAR | 354 | |
| chr18:22,020,051–22,020,863 | 149.0 kb | Distal (>10kb) Multiome HiCAR | 228 | |
| chr18:22,026,039–22,027,477 | 142.5 kb | Distal (>10kb) Multiome HiCAR | 321 | |
| chr18:22,079,674–22,080,842 | 89.3 kb | Distal (>10kb) Multiome | 105 | |
| chr18:22,093,896–22,094,823 | 75.0 kb | Distal (>10kb) Multiome | 197 | |
| chr18:22,101,589–22,102,358 | 67.5 kb | Distal (>10kb) Multiome | 40 | |
| chr18:22,110,470–22,110,946 | 58.7 kb | Distal (>10kb) Multiome | 169 | |
| chr18:22,158,498–22,160,201 | 10.2 kb | Distal (>10kb) Multiome | 129 | |
| chr18:22,161,645–22,162,076 | 7.4 kb | Proximal (<10kb) | 17 | |
| chr18:22,165,323–22,166,006 | 3.4 kb | Proximal (<10kb) | 73 | |
| chr18:22,167,956–22,172,162 | 184 bp | At TSS Multiome | 792 | |
| chr18:22,176,799–22,177,309 | 7.3 kb | Proximal (<10kb) | 146 | |
| chr18:22,178,046–22,178,875 | 8.6 kb | Proximal (<10kb) | 275 | |
| chr18:22,324,187–22,324,960 | 155.0 kb | Distal (>10kb) Multiome | 176 |
Genomic view of the GATA6-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.