The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GAP43. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GAP43 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GAP43, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:115,512,251–115,513,553 | 110.7 kb | Distal (>10kb) Multiome | 395 | |
| chr3:115,614,782–115,615,668 | 7.8 kb | Proximal (<10kb) | 134 | |
| chr3:115,623,092–115,624,078 | 50 bp | At TSS Multiome | 362 | |
| chr3:115,624,333–115,624,706 | 824 bp | At TSS | 97 | |
| chr3:115,624,831–115,625,170 | 1.3 kb | Proximal (<10kb) | 23 | |
| chr3:115,626,251–115,626,405 | 2.7 kb | Proximal (<10kb) | 19 | |
| chr3:115,627,178–115,627,730 | 3.7 kb | Proximal (<10kb) | 105 | |
| chr3:115,658,156–115,659,255 | 35.3 kb | Distal (>10kb) Multiome | 669 | |
| chr3:115,783,895–115,785,146 | 160.9 kb | Distal (>10kb) Multiome | 883 | |
| chr3:115,859,074–115,859,686 | 235.8 kb | Distal (>10kb) Multiome | 169 |
Genomic view of the GAP43 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.