This gene encodes a member of the GalNAc polypeptide N-acetylgalactosaminyltransferases. These enzymes catalyze the first step in the synthesis of mucin-type oligosaccharides. These proteins transfer GalNAc from UDP-GalNAc to either serine or threonine residues of polypeptide acceptors. The protein encoded by this locus may have increased catalytic activity toward glycosylated peptides compared to activity toward non-glycosylated peptides.[provided by RefSeq, Apr 2010]
Transcription factors with Perturb-seq knockdown data for GALNT10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GALNT10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GALNT10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:152,528,286–152,529,967 | 1662.2 kb | Distal (>10kb) Multiome HiCAR | 156 | |
| chr5:153,970,477–153,971,077 | 220.0 kb | Distal (>10kb) Multiome HiCAR | 31 | |
| chr5:154,038,273–154,039,479 | 151.8 kb | Distal (>10kb) Multiome HiCAR | 932 | |
| chr5:154,085,657–154,086,553 | 104.5 kb | Distal (>10kb) Multiome HiCAR | 155 | |
| chr5:154,107,450–154,108,420 | 82.8 kb | Distal (>10kb) Multiome HiCAR | 133 | |
| chr5:154,150,299–154,151,127 | 40.0 kb | Distal (>10kb) Multiome | 111 | |
| chr5:154,165,484–154,166,441 | 24.8 kb | Distal (>10kb) Multiome | 127 | |
| chr5:154,167,156–154,168,295 | 23.1 kb | Distal (>10kb) Multiome | 221 | |
| chr5:154,189,422–154,191,188 | 188 bp | At TSS Multiome | 748 | |
| chr5:154,194,364–154,194,955 | 3.6 kb | Proximal (<10kb) | 134 | |
| chr5:154,197,434–154,197,593 | 6.7 kb | Proximal (<10kb) | 278 | |
| chr5:154,286,422–154,287,475 | 96.0 kb | Distal (>10kb) Multiome | 301 | |
| chr5:154,384,486–154,385,397 | 193.9 kb | Distal (>10kb) Multiome HiCAR | 230 | |
| chr5:154,405,042–154,405,819 | 214.7 kb | Distal (>10kb) Multiome HiCAR | 447 | |
| chr5:154,444,815–154,447,315 | 255.2 kb | Distal (>10kb) Multiome HiCAR | 833 | |
| chr5:154,467,573–154,468,350 | 277.2 kb | Distal (>10kb) Multiome | 289 | |
| chr5:154,472,994–154,474,261 | 283.0 kb | Distal (>10kb) Multiome | 210 | |
| chr5:154,475,660–154,476,850 | 285.7 kb | Distal (>10kb) Multiome | 158 | |
| chr5:154,477,268–154,479,654 | 287.6 kb | Distal (>10kb) Multiome | 351 |
Genomic view of the GALNT10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.