GAL3ST4

galactose-3-O-sulfotransferase 4 | FLJ12116

This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate to the C-3' position of galactose residues in O-linked glycoproteins. This enzyme is highly specific for core 1 structures, with asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc being good substrates. [provided by RefSeq, Jul 2008]

Developmental clusters: GC2

Biological processes 18 terms

3'-phosphoadenosine 5'-phosphosulfate binding (GO:0050656)Golgi cisterna membrane (GO:0032580)cell-cell signaling (GO:0007267)extracellular exosome (GO:0070062)galactose 3-O-sulfotransferase activity (GO:0050694)galactose 3-O-sulfotransferase activity (GO:0050694)galactose 3-O-sulfotransferase activity (GO:0050694)galactosylceramide sulfotransferase activity (GO:0001733)glycolipid biosynthetic process (GO:0009247)glycoprotein biosynthetic process (GO:0009101)glycoprotein metabolic process (GO:0009100)membrane (GO:0016020)membrane (GO:0016020)membrane (GO:0016020)oligosaccharide metabolic process (GO:0009311)proteoglycan biosynthetic process (GO:0030166)proteoglycan sulfotransferase activity (GO:0050698)sulfur compound metabolic process (GO:0006790)

Expression (TPM)

TFs regulating GAL3ST4 0 TFs

Transcription factors with Perturb-seq knockdown data for GAL3ST4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GAL3ST4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to GAL3ST4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GAL3ST4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:99,929,116–99,929,724	239.1 kb	Distal (>10kb) Multiome	300
chr7:100,015,387–100,016,069	153.0 kb	Distal (>10kb) Multiome	744
chr7:100,049,441–100,050,060	118.8 kb	Distal (>10kb) Multiome	800
chr7:100,081,134–100,083,000	86.8 kb	Distal (>10kb) Multiome	1160
chr7:100,088,454–100,089,460	79.6 kb	Distal (>10kb) Multiome	955
chr7:100,100,270–100,102,380	68.0 kb	Distal (>10kb) Multiome	1102
chr7:100,119,029–100,120,415	49.1 kb	Distal (>10kb) Multiome	954
chr7:100,126,675–100,128,006	41.4 kb	Distal (>10kb) Multiome	919
chr7:100,148,262–100,149,663	19.8 kb	Distal (>10kb) Multiome	846
chr7:100,158,247–100,159,079	9.9 kb	Proximal (<10kb) Multiome	795
chr7:100,167,090–100,167,783	1.1 kb	Proximal (<10kb) Multiome	123
chr7:100,167,894–100,168,793	at TSS	At TSS	439
chr7:100,171,153–100,171,887	2.9 kb	Proximal (<10kb) Multiome	233
chr7:100,176,986–100,178,152	8.9 kb	Proximal (<10kb) Multiome	626
chr7:100,266,531–100,267,045	98.2 kb	Distal (>10kb) Multiome	24
chr7:100,270,225–100,270,813	102.0 kb	Distal (>10kb) Multiome	103
chr7:100,271,732–100,272,774	103.7 kb	Distal (>10kb) Multiome	530
chr7:100,335,652–100,336,470	167.5 kb	Distal (>10kb) Multiome HiCAR	706
chr7:100,381,682–100,382,670	213.4 kb	Distal (>10kb) Multiome	49
chr7:100,428,059–100,431,175	260.3 kb	Distal (>10kb) Multiome	1296
chr7:100,435,379–100,436,927	267.9 kb	Distal (>10kb) Multiome	931
chr7:100,450,379–100,450,973	282.1 kb	Distal (>10kb) Multiome	785

Genome Browser

Genomic view of the GAL3ST4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.