This gene encodes a protein containing two tryptophan-rich WW domains that binds the proline-rich formin homology 1 domains of formin family proteins, suggesting a role in the regulation of cytoskeletal dynamics during cell division and migration. It also binds intersectin family proteins suggesting a role in the maintenance of membrane curvature at sites of nascent vesicle formation. Naturally occurring mutations in this gene are associated with Waardenburg anophthalmia syndrome. [provided by RefSeq, Apr 2017]
Transcription factors with Perturb-seq knockdown data for FNBP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FNBP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FNBP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:47,508,005–47,509,036 | 258.7 kb | Distal (>10kb) Multiome | 73 | |
| chr11:47,552,255–47,553,700 | 214.0 kb | Distal (>10kb) Multiome | 834 | |
| chr11:47,564,988–47,566,330 | 201.7 kb | Distal (>10kb) Multiome | 842 | |
| chr11:47,578,427–47,579,510 | 188.3 kb | Distal (>10kb) Multiome | 1080 | |
| chr11:47,589,692–47,590,847 | 177.0 kb | Distal (>10kb) Multiome | 161 | |
| chr11:47,594,122–47,594,733 | 172.9 kb | Distal (>10kb) Multiome | 153 | |
| chr11:47,598,993–47,599,885 | 167.9 kb | Distal (>10kb) Multiome | 67 | |
| chr11:47,642,000–47,643,006 | 124.7 kb | Distal (>10kb) Multiome | 973 | |
| chr11:47,714,892–47,715,563 | 51.9 kb | Distal (>10kb) Multiome | 607 | |
| chr11:47,766,463–47,768,105 | 180 bp | At TSS Multiome | 961 | |
| chr11:47,847,845–47,848,997 | 81.1 kb | Distal (>10kb) Multiome | 863 | |
| chr11:47,916,144–47,917,140 | 149.4 kb | Distal (>10kb) Multiome | 336 | |
| chr11:47,943,718–47,944,629 | 176.8 kb | Distal (>10kb) Multiome | 269 | |
| chr11:47,979,218–47,981,637 | 213.2 kb | Distal (>10kb) Multiome | 548 |
Genomic view of the FNBP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.