The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FMNL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FMNL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FMNL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:49,538,551–49,539,219 | 168.5 kb | Distal (>10kb) Multiome | 284 | |
| chr12:49,550,509–49,551,225 | 156.4 kb | Distal (>10kb) Multiome | 126 | |
| chr12:49,567,505–49,568,696 | 139.3 kb | Distal (>10kb) Multiome | 807 | |
| chr12:49,622,768–49,624,150 | 83.9 kb | Distal (>10kb) Multiome HiCAR | 788 | |
| chr12:49,698,689–49,699,033 | 8.4 kb | Proximal (<10kb) | 177 | |
| chr12:49,706,780–49,708,002 | 191 bp | At TSS Multiome | 854 | |
| chr12:49,741,069–49,742,357 | 34.1 kb | Distal (>10kb) Multiome | 980 | |
| chr12:49,827,122–49,829,288 | 121.1 kb | Distal (>10kb) Multiome | 839 | |
| chr12:49,842,401–49,843,296 | 135.6 kb | Distal (>10kb) Multiome | 806 | |
| chr12:49,866,994–49,867,580 | 159.9 kb | Distal (>10kb) Multiome | 334 | |
| chr12:49,945,408–49,945,886 | 238.3 kb | Distal (>10kb) Multiome | 520 | |
| chr12:49,961,271–49,962,190 | 254.3 kb | Distal (>10kb) Multiome | 164 | |
| chr12:49,966,854–49,967,924 | 260.0 kb | Distal (>10kb) Multiome | 698 |
Genomic view of the FMNL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.