Transcription factors with Perturb-seq knockdown data for FHIP2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FHIP2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FHIP2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:21,788,264–21,790,181 | 300.2 kb | Distal (>10kb) Multiome | 307 | |
| chr8:21,812,040–21,812,512 | 276.9 kb | Distal (>10kb) Multiome | 199 | |
| chr8:21,918,240–21,920,671 | 169.6 kb | Distal (>10kb) Multiome | 727 | |
| chr8:22,009,978–22,010,924 | 78.8 kb | Distal (>10kb) Multiome | 885 | |
| chr8:22,024,029–22,025,514 | 63.9 kb | Distal (>10kb) Multiome | 508 | |
| chr8:22,036,665–22,037,480 | 52.2 kb | Distal (>10kb) Multiome | 457 | |
| chr8:22,039,647–22,043,111 | 49.1 kb | Distal (>10kb) Multiome | 407 | |
| chr8:22,047,856–22,051,849 | 40.0 kb | Distal (>10kb) Multiome | 566 | |
| chr8:22,052,727–22,057,283 | 35.2 kb | Distal (>10kb) Multiome | 541 | |
| chr8:22,066,266–22,067,293 | 22.3 kb | Distal (>10kb) Multiome | 612 | |
| chr8:22,069,764–22,070,311 | 19.1 kb | Distal (>10kb) Multiome | 85 | |
| chr8:22,089,006–22,089,746 | 14 bp | At TSS Multiome | 562 | |
| chr8:22,095,301–22,095,802 | 6.4 kb | Proximal (<10kb) Multiome | 199 | |
| chr8:22,108,625–22,110,515 | 20.3 kb | Distal (>10kb) Multiome | 907 | |
| chr8:22,129,779–22,131,071 | 41.3 kb | Distal (>10kb) Multiome HiCAR | 440 | |
| chr8:22,137,231–22,137,850 | 48.3 kb | Distal (>10kb) Multiome HiCAR | 531 | |
| chr8:22,140,995–22,142,545 | 52.7 kb | Distal (>10kb) Multiome | 753 | |
| chr8:22,156,517–22,157,091 | 67.7 kb | Distal (>10kb) Multiome | 215 | |
| chr8:22,164,354–22,165,830 | 75.8 kb | Distal (>10kb) Multiome | 672 | |
| chr8:22,176,636–22,177,193 | 87.8 kb | Distal (>10kb) Multiome | 91 | |
| chr8:22,188,487–22,189,031 | 99.6 kb | Distal (>10kb) Multiome | 334 | |
| chr8:22,244,388–22,245,751 | 156.0 kb | Distal (>10kb) Multiome | 1013 | |
| chr8:22,275,120–22,276,011 | 186.2 kb | Distal (>10kb) Multiome | 195 | |
| chr8:22,365,087–22,366,071 | 276.4 kb | Distal (>10kb) Multiome | 444 | |
| chr8:22,366,837–22,368,383 | 278.1 kb | Distal (>10kb) Multiome | 859 |
Genomic view of the FHIP2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.