This gene encodes a member of the fibroblast growth factor (FGF) family. Member of the FGF family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is expressed during embryogenesis and in the adult cerebellum and cortex and may be essential for vascular growth and normal brain development. Mutations in this gene are the cause of hypogonadotropic hypogonadism 20 with or without anosmia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Transcription factors with Perturb-seq knockdown data for FGF17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FGF17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FGF17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:21,782,177–21,783,108 | 261.9 kb | Distal (>10kb) Multiome | 145 | |
| chr8:21,784,384–21,784,867 | 260.0 kb | Distal (>10kb) Multiome | 246 | |
| chr8:21,788,264–21,790,181 | 255.5 kb | Distal (>10kb) Multiome | 307 | |
| chr8:21,918,240–21,920,671 | 125.0 kb | Distal (>10kb) Multiome | 727 | |
| chr8:22,009,978–22,010,924 | 34.2 kb | Distal (>10kb) Multiome | 885 | |
| chr8:22,036,665–22,037,480 | 7.6 kb | Proximal (<10kb) Multiome | 457 | |
| chr8:22,039,647–22,043,111 | 4.5 kb | Proximal (<10kb) Multiome | 407 | |
| chr8:22,043,945–22,044,848 | at TSS | At TSS | 106 | |
| chr8:22,047,856–22,051,849 | 4.7 kb | Proximal (<10kb) Multiome | 566 | |
| chr8:22,052,043–22,052,610 | 7.5 kb | Proximal (<10kb) | 39 | |
| chr8:22,052,727–22,057,283 | 9.4 kb | Proximal (<10kb) Multiome | 541 | |
| chr8:22,066,266–22,067,293 | 22.3 kb | Distal (>10kb) Multiome | 612 | |
| chr8:22,089,006–22,089,746 | 44.6 kb | Distal (>10kb) Multiome | 562 | |
| chr8:22,095,301–22,095,802 | 51.0 kb | Distal (>10kb) Multiome | 199 | |
| chr8:22,108,625–22,110,515 | 65.0 kb | Distal (>10kb) Multiome | 907 | |
| chr8:22,129,779–22,131,071 | 85.9 kb | Distal (>10kb) Multiome HiCAR | 440 | |
| chr8:22,137,231–22,137,850 | 92.9 kb | Distal (>10kb) Multiome HiCAR | 531 | |
| chr8:22,140,995–22,142,545 | 97.3 kb | Distal (>10kb) Multiome | 753 | |
| chr8:22,156,517–22,157,091 | 112.3 kb | Distal (>10kb) Multiome | 215 | |
| chr8:22,164,354–22,165,830 | 120.5 kb | Distal (>10kb) Multiome | 672 | |
| chr8:22,188,487–22,189,031 | 144.3 kb | Distal (>10kb) Multiome | 334 | |
| chr8:22,244,388–22,245,751 | 200.6 kb | Distal (>10kb) Multiome | 1013 | |
| chr8:22,275,120–22,276,011 | 230.8 kb | Distal (>10kb) Multiome | 195 |
Genomic view of the FGF17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.