This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FBXO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:11,478,503–11,480,383 | 175.4 kb | Distal (>10kb) Multiome | 732 | |
| chr1:11,563,348–11,564,005 | 90.7 kb | Distal (>10kb) Multiome | 272 | |
| chr1:11,645,786–11,645,954 | 8.5 kb | Proximal (<10kb) | 110 | |
| chr1:11,648,764–11,649,139 | 5.3 kb | Proximal (<10kb) | 150 | |
| chr1:11,650,273–11,650,925 | 3.9 kb | Proximal (<10kb) Multiome | 495 | |
| chr1:11,653,905–11,655,506 | 343 bp | At TSS Multiome | 476 | |
| chr1:11,663,895–11,664,883 | 9.8 kb | Proximal (<10kb) Multiome | 644 | |
| chr1:11,680,428–11,681,928 | 26.8 kb | Distal (>10kb) Multiome | 820 | |
| chr1:11,682,348–11,682,757 | 28.3 kb | Distal (>10kb) Multiome | 94 | |
| chr1:11,690,815–11,692,563 | 37.3 kb | Distal (>10kb) Multiome | 361 | |
| chr1:11,735,752–11,736,686 | 81.7 kb | Distal (>10kb) Multiome | 714 | |
| chr1:11,784,926–11,785,439 | 130.9 kb | Distal (>10kb) Multiome | 531 | |
| chr1:11,802,827–11,804,002 | 149.2 kb | Distal (>10kb) Multiome | 507 | |
| chr1:11,805,133–11,806,702 | 151.6 kb | Distal (>10kb) Multiome | 1034 | |
| chr1:11,876,145–11,876,721 | 222.0 kb | Distal (>10kb) Multiome | 56 | |
| chr1:11,907,175–11,910,389 | 254.0 kb | Distal (>10kb) Multiome | 1299 | |
| chr1:11,925,969–11,926,788 | 272.1 kb | Distal (>10kb) Multiome | 632 | |
| chr1:11,934,261–11,935,008 | 280.2 kb | Distal (>10kb) Multiome | 809 |
Genomic view of the FBXO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.