Predicted to enable calcium ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to act upstream of or within generation of neurons; negative regulation of dendrite development; and retina layer formation. Predicted to be located in dendrite and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for FAT3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAT3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAT3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:91,959,230–91,959,993 | 265.2 kb | Distal (>10kb) Multiome | 110 | |
| chr11:92,216,789–92,217,714 | 7.1 kb | Proximal (<10kb) | 147 | |
| chr11:92,223,461–92,224,264 | 552 bp | At TSS | 75 | |
| chr11:92,224,363–92,227,647 | 2.2 kb | Proximal (<10kb) Multiome | 447 | |
| chr11:92,311,626–92,312,449 | 87.1 kb | Distal (>10kb) Multiome HiCAR | 124 | |
| chr11:92,511,593–92,512,150 | 287.2 kb | Distal (>10kb) Multiome | 114 | |
| chr11:92,550,231–92,550,765 | 325.8 kb | Distal (>10kb) Multiome HiCAR | 135 |
Genomic view of the FAT3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.