Involved in positive regulation of canonical Wnt signaling pathway. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAM53B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM53B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM53B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:124,448,804–124,450,505 | 294.2 kb | Distal (>10kb) Multiome | 289 | |
| chr10:124,461,513–124,462,370 | 282.4 kb | Distal (>10kb) Multiome | 629 | |
| chr10:124,469,789–124,470,407 | 274.2 kb | Distal (>10kb) Multiome | 215 | |
| chr10:124,565,553–124,566,190 | 178.5 kb | Distal (>10kb) Multiome | 253 | |
| chr10:124,739,557–124,739,910 | 3.1 kb | Proximal (<10kb) | 58 | |
| chr10:124,741,192–124,741,643 | 1.3 kb | Proximal (<10kb) | 336 | |
| chr10:124,742,452–124,743,093 | at TSS | At TSS | 288 | |
| chr10:124,743,297–124,744,966 | 12 bp | At TSS Multiome | 546 | |
| chr10:124,791,269–124,792,470 | 47.5 kb | Distal (>10kb) Multiome | 976 | |
| chr10:124,800,254–124,802,352 | 57.5 kb | Distal (>10kb) Multiome | 821 | |
| chr10:124,916,459–124,917,959 | 172.5 kb | Distal (>10kb) Multiome | 843 |
Genomic view of the FAM53B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.