Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAM222B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM222B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM222B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:28,551,965–28,553,140 | 290.1 kb | Distal (>10kb) Multiome | 557 | |
| chr17:28,570,861–28,571,983 | 271.2 kb | Distal (>10kb) Multiome | 701 | |
| chr17:28,576,649–28,577,524 | 265.8 kb | Distal (>10kb) Multiome | 652 | |
| chr17:28,598,491–28,599,842 | 243.7 kb | Distal (>10kb) Multiome | 810 | |
| chr17:28,621,936–28,622,562 | 220.4 kb | Distal (>10kb) Multiome | 55 | |
| chr17:28,644,541–28,645,596 | 197.6 kb | Distal (>10kb) Multiome | 795 | |
| chr17:28,661,635–28,662,527 | 180.7 kb | Distal (>10kb) Multiome | 809 | |
| chr17:28,710,720–28,712,813 | 131.4 kb | Distal (>10kb) Multiome | 892 | |
| chr17:28,717,030–28,718,784 | 124.9 kb | Distal (>10kb) Multiome | 492 | |
| chr17:28,718,918–28,720,313 | 123.0 kb | Distal (>10kb) Multiome | 927 | |
| chr17:28,724,652–28,729,474 | 115.7 kb | Distal (>10kb) Multiome | 1286 | |
| chr17:28,743,083–28,744,926 | 98.7 kb | Distal (>10kb) Multiome | 991 | |
| chr17:28,745,076–28,746,436 | 97.2 kb | Distal (>10kb) Multiome | 568 | |
| chr17:28,749,859–28,750,549 | 92.6 kb | Distal (>10kb) Multiome | 550 | |
| chr17:28,811,615–28,812,945 | 30.3 kb | Distal (>10kb) Multiome | 699 | |
| chr17:28,842,307–28,843,098 | 9 bp | At TSS Multiome | 717 | |
| chr17:28,854,460–28,855,289 | 12.1 kb | Distal (>10kb) Multiome | 780 | |
| chr17:28,896,962–28,898,028 | 54.8 kb | Distal (>10kb) Multiome | 846 | |
| chr17:28,902,302–28,903,488 | 60.3 kb | Distal (>10kb) Multiome | 967 | |
| chr17:28,950,281–28,952,708 | 108.9 kb | Distal (>10kb) Multiome | 989 | |
| chr17:28,984,463–28,984,954 | 141.8 kb | Distal (>10kb) Multiome | 33 | |
| chr17:28,985,971–28,986,457 | 143.4 kb | Distal (>10kb) Multiome | 123 | |
| chr17:29,005,841–29,006,414 | 163.3 kb | Distal (>10kb) Multiome | 707 | |
| chr17:29,039,928–29,040,500 | 197.4 kb | Distal (>10kb) Multiome | 99 | |
| chr17:29,042,531–29,043,259 | 200.1 kb | Distal (>10kb) Multiome | 553 |
Genomic view of the FAM222B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.