Involved in mitotic spindle organization. Located in cytosol; microtubule cytoskeleton; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAM110A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM110A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM110A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:543,069–544,398 | 289.9 kb | Distal (>10kb) Multiome | 965 | |
| chr20:555,914–556,523 | 277.6 kb | Distal (>10kb) Multiome | 249 | |
| chr20:574,398–574,909 | 259.1 kb | Distal (>10kb) Multiome | 119 | |
| chr20:609,984–610,596 | 223.4 kb | Distal (>10kb) Multiome | 205 | |
| chr20:652,813–653,697 | 180.4 kb | Distal (>10kb) Multiome | 897 | |
| chr20:675,301–676,096 | 158.1 kb | Distal (>10kb) Multiome | 782 | |
| chr20:709,891–710,669 | 123.6 kb | Distal (>10kb) Multiome | 168 | |
| chr20:727,954–728,888 | 105.3 kb | Distal (>10kb) Multiome | 621 | |
| chr20:775,602–776,151 | 57.8 kb | Distal (>10kb) Multiome | 126 | |
| chr20:790,861–791,409 | 42.6 kb | Distal (>10kb) Multiome | 25 | |
| chr20:833,367–834,334 | 132 bp | At TSS Multiome | 839 | |
| chr20:841,152–841,673 | 7.4 kb | Proximal (<10kb) | 311 | |
| chr20:841,821–842,567 | 8.6 kb | Proximal (<10kb) Multiome | 248 | |
| chr20:844,437–845,353 | 10.8 kb | Distal (>10kb) Multiome | 299 | |
| chr20:884,981–885,530 | 51.4 kb | Distal (>10kb) Multiome | 183 | |
| chr20:955,007–955,547 | 121.5 kb | Distal (>10kb) Multiome HiCAR | 24 | |
| chr20:1,001,978–1,002,815 | 168.7 kb | Distal (>10kb) Multiome | 124 | |
| chr20:1,061,388–1,061,918 | 227.9 kb | Distal (>10kb) Multiome | 105 | |
| chr20:1,118,327–1,119,071 | 284.8 kb | Distal (>10kb) Multiome | 1066 |
Genomic view of the FAM110A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.