ERI3

ERI1 exoribonuclease family member 3 | FLJ22943, PINT1, PRNPIP

Enables RNA binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-2 DE-2.44

Biological processes 7 terms

3'-5'-RNA exonuclease activity (GO:0000175)3'-5'-RNA exonuclease activity (GO:0000175)RNA binding (GO:0003723)cytosol (GO:0005829)exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000467)negative regulation of regulatory ncRNA-mediated heterochromatin formation (GO:0060906)nucleic acid binding (GO:0003676)

Expression (TPM)

TFs regulating ERI3 0 TFs

Transcription factors with Perturb-seq knockdown data for ERI3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ERI3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ERI3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ERI3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:44,134,442–44,134,897	220.6 kb	Distal (>10kb) Multiome	32
chr1:44,213,251–44,213,777	141.8 kb	Distal (>10kb) Multiome	1062
chr1:44,238,024–44,238,695	116.9 kb	Distal (>10kb) Multiome	396
chr1:44,240,892–44,241,669	114.0 kb	Distal (>10kb) Multiome	103
chr1:44,290,412–44,291,163	64.4 kb	Distal (>10kb) Multiome	270
chr1:44,316,195–44,316,964	38.7 kb	Distal (>10kb) Multiome	103
chr1:44,354,715–44,355,536	11 bp	At TSS Multiome	626
chr1:44,404,952–44,406,390	50.0 kb	Distal (>10kb) Multiome	647
chr1:44,417,400–44,418,123	62.4 kb	Distal (>10kb) Multiome	272
chr1:44,500,703–44,501,235	145.8 kb	Distal (>10kb) Multiome	128
chr1:44,512,396–44,512,984	157.4 kb	Distal (>10kb) Multiome	68
chr1:44,523,679–44,524,641	169.0 kb	Distal (>10kb) Multiome	302
chr1:44,542,481–44,544,064	188.0 kb	Distal (>10kb) Multiome	277
chr1:44,631,466–44,632,956	276.8 kb	Distal (>10kb) Multiome	928

Genome Browser

Genomic view of the ERI3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.