This gene encodes a member of the SWItch/Sucrose Non-Fermentable (SWI/SNF2) family of proteins, and contains a SNF2-like ATPase domain and a PICH family domain. One distinguishing feature of this SWI/SNF protein family member is that during interphase, the protein is excluded from the nucleus, and only associates with chromatin after the nuclear envelope has broken down. This protein is a DNA translocase that is thought to bind double-stranded DNA that is exposed to stretching forces, such as those exerted by the mitotic spindle. This protein associates with ribosomal DNA and ultra-fine DNA bridges (UFBs), fine structures that connect sister chromatids during anaphase at some sites such as fragile sites, telomeres and centromeres. This gene is required for the faithful segregation of sister chromatids during mitosis, and the ATPase activity of this protein required for the resolution of UFBs before cytokinesis. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for ERCC6L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ERCC6L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ERCC6L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:71,957,980–71,958,453 | 280.9 kb | Distal (>10kb) Multiome | 90 | |
| chrX:72,018,244–72,018,883 | 220.4 kb | Distal (>10kb) Multiome | 577 | |
| chrX:72,115,329–72,115,816 | 123.4 kb | Distal (>10kb) Multiome | 75 | |
| chrX:72,131,595–72,132,294 | 107.0 kb | Distal (>10kb) Multiome | 266 | |
| chrX:72,181,219–72,182,040 | 57.5 kb | Distal (>10kb) Multiome | 619 | |
| chrX:72,238,686–72,239,464 | 69 bp | At TSS Multiome | 448 | |
| chrX:72,245,585–72,245,769 | 6.6 kb | Proximal (<10kb) | 118 | |
| chrX:72,276,823–72,277,642 | 38.2 kb | Distal (>10kb) Multiome | 768 |
Genomic view of the ERCC6L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.