This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for EPN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:19,003,639–19,005,123 | 233.1 kb | Distal (>10kb) Multiome | 733 | |
| chr17:19,237,368–19,238,388 | 44 bp | At TSS Multiome | 509 | |
| chr17:19,317,172–19,317,657 | 79.9 kb | Distal (>10kb) Multiome HiCAR | 467 | |
| chr17:19,362,100–19,363,673 | 125.4 kb | Distal (>10kb) Multiome | 804 | |
| chr17:19,377,561–19,379,155 | 140.8 kb | Distal (>10kb) Multiome | 877 | |
| chr17:19,386,868–19,387,884 | 149.8 kb | Distal (>10kb) Multiome | 305 | |
| chr17:19,433,247–19,433,662 | 196.0 kb | Distal (>10kb) Multiome | 30 | |
| chr17:19,455,896–19,456,558 | 218.7 kb | Distal (>10kb) Multiome | 43 | |
| chr17:19,457,529–19,459,378 | 220.6 kb | Distal (>10kb) Multiome | 100 | |
| chr17:19,460,682–19,461,395 | 223.7 kb | Distal (>10kb) Multiome | 93 | |
| chr17:19,507,283–19,508,789 | 270.6 kb | Distal (>10kb) Multiome | 842 | |
| chr17:19,519,787–19,520,274 | 282.5 kb | Distal (>10kb) Multiome | 130 | |
| chr17:19,533,700–19,534,412 | 296.4 kb | Distal (>10kb) Multiome | 488 |
Genomic view of the EPN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.