Predicted to enable ATP hydrolysis activity; ATP-dependent DNA damage sensor activity; and kinase activity. Predicted to be involved in mismatch repair. Predicted to be part of mismatch repair complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ENSG00000291178. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291178 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291178, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:100,049,441–100,050,060 | 286.2 kb | Distal (>10kb) Multiome | 800 | |
| chr7:100,081,134–100,083,000 | 254.1 kb | Distal (>10kb) Multiome | 1160 | |
| chr7:100,088,454–100,089,460 | 247.0 kb | Distal (>10kb) Multiome | 955 | |
| chr7:100,100,270–100,102,380 | 235.3 kb | Distal (>10kb) Multiome | 1102 | |
| chr7:100,119,029–100,120,415 | 216.4 kb | Distal (>10kb) Multiome | 954 | |
| chr7:100,126,675–100,128,006 | 208.7 kb | Distal (>10kb) Multiome | 919 | |
| chr7:100,148,262–100,149,663 | 187.1 kb | Distal (>10kb) Multiome | 846 | |
| chr7:100,158,247–100,159,079 | 177.2 kb | Distal (>10kb) Multiome | 795 | |
| chr7:100,167,090–100,167,783 | 168.5 kb | Distal (>10kb) Multiome HiCAR | 123 | |
| chr7:100,167,894–100,168,793 | 167.3 kb | Distal (>10kb) Multiome | 439 | |
| chr7:100,171,153–100,171,887 | 164.5 kb | Distal (>10kb) Multiome | 233 | |
| chr7:100,176,986–100,178,152 | 158.4 kb | Distal (>10kb) Multiome | 626 | |
| chr7:100,266,531–100,267,045 | 69.2 kb | Distal (>10kb) Multiome HiCAR | 24 | |
| chr7:100,270,225–100,270,813 | 65.3 kb | Distal (>10kb) Multiome HiCAR | 103 | |
| chr7:100,271,732–100,272,774 | 63.6 kb | Distal (>10kb) Multiome HiCAR | 530 | |
| chr7:100,335,652–100,336,470 | 136 bp | At TSS Multiome | 706 | |
| chr7:100,381,682–100,382,670 | 46.1 kb | Distal (>10kb) Multiome | 49 | |
| chr7:100,428,059–100,431,175 | 93.0 kb | Distal (>10kb) Multiome | 1296 | |
| chr7:100,435,379–100,436,927 | 100.6 kb | Distal (>10kb) Multiome | 931 | |
| chr7:100,450,379–100,450,973 | 114.7 kb | Distal (>10kb) Multiome | 785 | |
| chr7:100,478,582–100,479,753 | 143.4 kb | Distal (>10kb) Multiome | 842 | |
| chr7:100,482,937–100,484,533 | 147.7 kb | Distal (>10kb) Multiome | 677 | |
| chr7:100,538,557–100,539,759 | 203.1 kb | Distal (>10kb) Multiome | 858 | |
| chr7:100,542,221–100,542,986 | 206.7 kb | Distal (>10kb) Multiome | 274 | |
| chr7:100,569,177–100,570,642 | 233.7 kb | Distal (>10kb) Multiome | 855 | |
| chr7:100,585,161–100,587,241 | 250.4 kb | Distal (>10kb) Multiome | 966 | |
| chr7:100,611,685–100,612,981 | 276.3 kb | Distal (>10kb) Multiome | 767 | |
| chr7:100,626,427–100,627,057 | 290.8 kb | Distal (>10kb) Multiome | 415 |
Genomic view of the ENSG00000291178 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.