Transcription factors with Perturb-seq knockdown data for ENSG00000290073. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290073 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290073, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:52,335,886–52,336,825 | 265.1 kb | Distal (>10kb) Multiome | 373 | |
| chr19:52,338,866–52,339,647 | 261.9 kb | Distal (>10kb) Multiome | 56 | |
| chr19:52,492,205–52,493,529 | 108.4 kb | Distal (>10kb) Multiome | 178 | |
| chr19:52,526,868–52,528,322 | 73.8 kb | Distal (>10kb) Multiome | 602 | |
| chr19:52,535,433–52,536,654 | 65.3 kb | Distal (>10kb) Multiome | 273 | |
| chr19:52,558,780–52,559,576 | 42.1 kb | Distal (>10kb) Multiome | 17 | |
| chr19:52,569,672–52,570,898 | 31.1 kb | Distal (>10kb) Multiome | 555 | |
| chr19:52,599,357–52,599,636 | 1.6 kb | Proximal (<10kb) | 9 | |
| chr19:52,600,732–52,601,970 | 68 bp | At TSS Multiome | 412 | |
| chr19:52,602,079–52,602,257 | 805 bp | At TSS | 40 | |
| chr19:52,637,710–52,638,958 | 37.1 kb | Distal (>10kb) Multiome | 473 | |
| chr19:52,690,252–52,691,142 | 89.3 kb | Distal (>10kb) Multiome | 540 | |
| chr19:52,734,568–52,736,125 | 134.8 kb | Distal (>10kb) Multiome | 473 | |
| chr19:52,741,322–52,742,486 | 141.0 kb | Distal (>10kb) Multiome | 114 | |
| chr19:52,786,717–52,787,643 | 185.6 kb | Distal (>10kb) Multiome | 439 | |
| chr19:52,857,376–52,858,206 | 256.5 kb | Distal (>10kb) Multiome | 332 | |
| chr19:52,896,852–52,898,438 | 296.4 kb | Distal (>10kb) Multiome | 488 |
Genomic view of the ENSG00000290073 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.