Transcription factors with Perturb-seq knockdown data for ENSG00000289894. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289894 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289894, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:50,909,544–50,910,786 | 259.7 kb | Distal (>10kb) Multiome | 827 | |
| chr13:51,101,590–51,102,215 | 67.8 kb | Distal (>10kb) Multiome | 123 | |
| chr13:51,122,652–51,123,430 | 46.5 kb | Distal (>10kb) Multiome | 298 | |
| chr13:51,125,567–51,126,048 | 43.8 kb | Distal (>10kb) Multiome | 224 | |
| chr13:51,146,222–51,147,378 | 22.8 kb | Distal (>10kb) Multiome | 79 | |
| chr13:51,147,892–51,149,246 | 21.1 kb | Distal (>10kb) Multiome | 319 | |
| chr13:51,169,207–51,170,289 | 306 bp | At TSS Multiome | 174 | |
| chr13:51,171,477–51,171,724 | 1.9 kb | Proximal (<10kb) | 3 | |
| chr13:51,175,033–51,175,343 | 5.5 kb | Proximal (<10kb) | 21 | |
| chr13:51,178,352–51,178,770 | 8.8 kb | Proximal (<10kb) | 16 | |
| chr13:51,221,124–51,223,194 | 52.6 kb | Distal (>10kb) Multiome HiCAR | 488 | |
| chr13:51,243,717–51,244,186 | 74.3 kb | Distal (>10kb) Multiome | 185 | |
| chr13:51,244,496–51,245,455 | 75.6 kb | Distal (>10kb) Multiome | 117 | |
| chr13:51,303,027–51,303,676 | 133.7 kb | Distal (>10kb) Multiome | 130 | |
| chr13:51,451,249–51,454,202 | 282.2 kb | Distal (>10kb) Multiome | 1037 |
Genomic view of the ENSG00000289894 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.