Transcription factors with Perturb-seq knockdown data for ENSG00000286279. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286279 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286279, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:57,751,806–57,753,147 | 1570.3 kb | Distal (>10kb) Multiome HiCAR | 1030 | |
| chr12:57,754,455–57,756,188 | 1567.8 kb | Distal (>10kb) Multiome HiCAR | 616 | |
| chr12:57,756,649–57,757,193 | 1565.8 kb | Distal (>10kb) Multiome HiCAR | 315 | |
| chr12:57,852,281–57,853,469 | 1469.9 kb | Distal (>10kb) Multiome HiCAR | 295 | |
| chr12:58,206,630–58,207,741 | 1115.6 kb | Distal (>10kb) Multiome HiCAR | 155 | |
| chr12:59,074,983–59,076,039 | 247.2 kb | Distal (>10kb) Multiome | 168 | |
| chr12:59,316,403–59,316,689 | 6.1 kb | Proximal (<10kb) | 12 | |
| chr12:59,317,267–59,318,030 | 5.0 kb | Proximal (<10kb) Multiome | 138 | |
| chr12:59,318,808–59,319,168 | 3.6 kb | Proximal (<10kb) | 12 | |
| chr12:59,320,703–59,321,012 | 1.8 kb | Proximal (<10kb) | 11 | |
| chr12:59,322,457–59,323,048 | at TSS | At TSS | 61 | |
| chr12:59,323,152–59,323,908 | 388 bp | At TSS | 86 | |
| chr12:59,326,922–59,327,399 | 4.2 kb | Proximal (<10kb) | 4 | |
| chr12:59,328,376–59,329,451 | 6.0 kb | Proximal (<10kb) Multiome | 131 | |
| chr12:59,368,115–59,368,972 | 45.8 kb | Distal (>10kb) Multiome | 162 | |
| chr12:59,595,540–59,597,709 | 273.4 kb | Distal (>10kb) Multiome | 708 |
Genomic view of the ENSG00000286279 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.