Transcription factors with Perturb-seq knockdown data for ENSG00000283689. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000283689 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000283689, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:54,281,564–54,282,249 | 3.4 kb | Proximal (<10kb) | 131 | |
| chr16:54,282,317–54,283,163 | 2.4 kb | Proximal (<10kb) | 207 | |
| chr16:54,283,950–54,287,988 | at TSS | At TSS | 857 | |
| chr16:54,289,334–54,289,776 | 3.7 kb | Proximal (<10kb) | 105 | |
| chr16:54,291,177–54,291,532 | 5.6 kb | Proximal (<10kb) | 69 | |
| chr16:54,291,618–54,292,104 | 6.0 kb | Proximal (<10kb) | 56 | |
| chr16:54,292,246–54,292,560 | 6.6 kb | Proximal (<10kb) | 32 |
Genomic view of the ENSG00000283689 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.