Transcription factors with Perturb-seq knockdown data for ENSG00000271811. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000271811 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000271811, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:170,660,158–170,660,691 | 6.7 kb | Proximal (<10kb) | 60 | |
| chr1:170,660,944–170,662,628 | 4.8 kb | Proximal (<10kb) | 217 | |
| chr1:170,662,985–170,663,591 | 3.8 kb | Proximal (<10kb) | 84 | |
| chr1:170,663,964–170,665,497 | 1.9 kb | Proximal (<10kb) | 357 | |
| chr1:170,665,688–170,666,019 | 1.4 kb | Proximal (<10kb) | 48 | |
| chr1:170,666,646–170,667,067 | 312 bp | At TSS | 86 | |
| chr1:170,667,162–170,667,706 | at TSS | At TSS | 75 | |
| chr1:170,668,159–170,669,041 | 779 bp | At TSS | 182 | |
| chr1:170,671,189–170,671,827 | 3.8 kb | Proximal (<10kb) | 133 |
Genomic view of the ENSG00000271811 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.