Transcription factors with Perturb-seq knockdown data for ENSG00000256417. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000256417 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000256417, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:5,043,628–5,044,415 | 246.4 kb | Distal (>10kb) Multiome | 156 | |
| chr12:5,276,469–5,277,121 | 13.8 kb | Distal (>10kb) Multiome HiCAR | 66 | |
| chr12:5,391,547–5,392,219 | 101.4 kb | Distal (>10kb) Multiome | 61 | |
| chr12:5,429,658–5,430,402 | 139.6 kb | Distal (>10kb) Multiome | 66 | |
| chr12:5,480,189–5,480,764 | 190.0 kb | Distal (>10kb) Multiome | 72 |
Genomic view of the ENSG00000256417 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.