ENC1
ectodermal-neural cortex 1 | ENC-1, KLHL37, PIG10, TP53I10, NRPB

This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Member of: DE-4 DE-4.30 Developmental clusters: GC6
Biological processes 22 terms
Cul3-RING ubiquitin ligase complex (GO:0031463)Cul3-RING ubiquitin ligase complex (GO:0031463)Cul3-RING ubiquitin ligase complex (GO:0031463)chromatin (GO:0000785)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoskeleton (GO:0005856)negative regulation of translation (GO:0017148)nervous system development (GO:0007399)neuronal cell body (GO:0043025)nuclear matrix (GO:0016363)nucleoplasm (GO:0005654)nucleus (GO:0005634)positive regulation of neuron projection development (GO:0010976)proteasomal ubiquitin-independent protein catabolic process (GO:0010499)proteasomal ubiquitin-independent protein catabolic process (GO:0010499)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)protein ubiquitination (GO:0016567)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-like ligase-substrate adaptor activity (GO:1990756)
Expression (TPM)
ENC1 — as a Regulated Gene

TFs regulating ENC1 0 TFs

Transcription factors with Perturb-seq knockdown data for ENC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ENC1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr5:73,795,627–73,796,633 844.7 kb Distal (>10kb) Multiome HiCAR 254
chr5:74,105,147–74,105,887 535.2 kb Distal (>10kb) Multiome HiCAR 169
chr5:74,507,243–74,508,516 132.8 kb Distal (>10kb) Multiome 61
chr5:74,515,759–74,516,668 124.4 kb Distal (>10kb) Multiome 152
chr5:74,536,561–74,538,457 102.9 kb Distal (>10kb) Multiome 426
chr5:74,543,139–74,544,218 97.1 kb Distal (>10kb) Multiome 418
chr5:74,555,513–74,556,350 84.6 kb Distal (>10kb) Multiome 100
chr5:74,625,689–74,626,268 14.7 kb Distal (>10kb) Multiome 148
chr5:74,631,192–74,632,778 9.2 kb Proximal (<10kb) Multiome 598
chr5:74,639,680–74,641,657 91 bp At TSS Multiome 999
chr5:74,641,786–74,642,280 1.1 kb Proximal (<10kb) 260
chr5:74,648,865–74,649,083 8.1 kb Proximal (<10kb) 240
chr5:74,684,927–74,685,413 44.5 kb Distal (>10kb) Multiome 765
chr5:74,766,697–74,767,753 126.5 kb Distal (>10kb) Multiome 976
chr5:74,865,358–74,867,179 225.6 kb Distal (>10kb) Multiome 747
chr5:74,882,799–74,883,395 242.2 kb Distal (>10kb) Multiome 109
chr5:74,903,262–74,903,711 262.8 kb Distal (>10kb) Multiome 301

Genome Browser

Genomic view of the ENC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr5:73,785,627 – 74,913,711
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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