Predicted to enable cholestenol delta-isomerase activity. Predicted to be involved in sterol metabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EBPL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EBPL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EBPL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:49,443,422–49,445,325 | 247.3 kb | Distal (>10kb) Multiome | 929 | |
| chr13:49,495,326–49,496,757 | 195.3 kb | Distal (>10kb) Multiome | 729 | |
| chr13:49,559,958–49,561,357 | 130.6 kb | Distal (>10kb) Multiome | 297 | |
| chr13:49,584,820–49,586,364 | 105.8 kb | Distal (>10kb) Multiome | 809 | |
| chr13:49,628,213–49,628,711 | 63.0 kb | Distal (>10kb) Multiome | 271 | |
| chr13:49,635,533–49,636,248 | 55.7 kb | Distal (>10kb) Multiome | 74 | |
| chr13:49,664,328–49,664,981 | 26.7 kb | Distal (>10kb) Multiome | 75 | |
| chr13:49,690,816–49,691,882 | 27 bp | At TSS Multiome | 847 | |
| chr13:49,791,339–49,793,749 | 101.4 kb | Distal (>10kb) Multiome HiCAR | 930 | |
| chr13:49,847,783–49,848,275 | 156.7 kb | Distal (>10kb) Multiome HiCAR | 505 | |
| chr13:49,935,563–49,937,380 | 245.0 kb | Distal (>10kb) Multiome | 924 |
Genomic view of the EBPL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.