This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for DUSP16. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DUSP16 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DUSP16, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:12,266,376–12,267,615 | 295.7 kb | Distal (>10kb) Multiome | 1095 | |
| chr12:12,349,790–12,350,566 | 212.6 kb | Distal (>10kb) Multiome HiCAR | 671 | |
| chr12:12,356,841–12,357,808 | 205.7 kb | Distal (>10kb) Multiome HiCAR | 912 | |
| chr12:12,561,525–12,563,261 | 52 bp | At TSS Multiome | 768 | |
| chr12:12,564,052–12,564,303 | 2.9 kb | Proximal (<10kb) | 311 | |
| chr12:12,611,502–12,612,657 | 49.0 kb | Distal (>10kb) Multiome | 980 | |
| chr12:12,684,299–12,685,064 | 121.9 kb | Distal (>10kb) Multiome | 306 | |
| chr12:12,693,129–12,694,039 | 130.7 kb | Distal (>10kb) Multiome HiCAR | 190 | |
| chr12:12,695,955–12,697,008 | 133.5 kb | Distal (>10kb) Multiome HiCAR | 568 | |
| chr12:12,716,729–12,717,910 | 154.4 kb | Distal (>10kb) Multiome | 799 | |
| chr12:12,723,708–12,726,164 | 162.7 kb | Distal (>10kb) Multiome | 958 | |
| chr12:12,742,773–12,743,975 | 180.4 kb | Distal (>10kb) Multiome | 118 | |
| chr12:12,775,741–12,776,742 | 213.5 kb | Distal (>10kb) Multiome | 267 | |
| chr12:12,786,507–12,787,490 | 224.1 kb | Distal (>10kb) Multiome | 739 | |
| chr12:12,799,298–12,799,907 | 236.8 kb | Distal (>10kb) Multiome | 137 | |
| chr12:12,812,936–12,813,661 | 250.4 kb | Distal (>10kb) Multiome | 700 |
Genomic view of the DUSP16 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.