Enables tRNA-uridine aminocarboxypropyltransferase activity. Involved in RNA glycosylation and tRNA modification. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DTWD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DTWD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DTWD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:118,951,671–118,953,627 | 36.1 kb | Distal (>10kb) Multiome | 243 | |
| chr5:118,987,706–118,989,045 | 54 bp | At TSS Multiome | 941 | |
| chr5:118,989,856–118,990,341 | 1.6 kb | Proximal (<10kb) | 94 | |
| chr5:118,990,659–118,990,835 | 2.4 kb | Proximal (<10kb) | 64 | |
| chr5:119,070,182–119,071,897 | 82.5 kb | Distal (>10kb) Multiome | 975 | |
| chr5:119,255,677–119,256,535 | 267.6 kb | Distal (>10kb) Multiome HiCAR | 184 | |
| chr5:119,267,854–119,269,617 | 280.1 kb | Distal (>10kb) Multiome | 918 | |
| chr5:119,409,419–119,410,763 | 421.7 kb | Distal (>10kb) Multiome HiCAR | 149 | |
| chr5:119,452,092–119,453,354 | 464.1 kb | Distal (>10kb) Multiome HiCAR | 894 |
Genomic view of the DTWD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.