This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. [provided by RefSeq, Dec 2014]
Transcription factors with Perturb-seq knockdown data for DNAL4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAL4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAL4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:38,505,466–38,506,961 | 287.6 kb | Distal (>10kb) Multiome | 889 | |
| chr22:38,569,664–38,571,256 | 223.8 kb | Distal (>10kb) Multiome | 559 | |
| chr22:38,655,982–38,657,104 | 137.7 kb | Distal (>10kb) Multiome | 698 | |
| chr22:38,681,730–38,682,262 | 112.2 kb | Distal (>10kb) Multiome | 947 | |
| chr22:38,700,377–38,701,744 | 93.2 kb | Distal (>10kb) Multiome | 916 | |
| chr22:38,705,151–38,706,595 | 88.5 kb | Distal (>10kb) Multiome | 821 | |
| chr22:38,755,428–38,756,383 | 38.1 kb | Distal (>10kb) Multiome | 770 | |
| chr22:38,793,674–38,794,378 | 7 bp | At TSS Multiome | 484 | |
| chr22:38,843,207–38,844,443 | 49.7 kb | Distal (>10kb) Multiome | 585 | |
| chr22:38,866,394–38,866,832 | 72.4 kb | Distal (>10kb) Multiome | 76 | |
| chr22:38,871,208–38,873,237 | 78.2 kb | Distal (>10kb) Multiome | 758 | |
| chr22:39,014,028–39,014,530 | 220.1 kb | Distal (>10kb) Multiome | 367 | |
| chr22:39,020,588–39,021,215 | 226.8 kb | Distal (>10kb) Multiome | 149 | |
| chr22:39,040,158–39,041,304 | 246.8 kb | Distal (>10kb) Multiome | 237 | |
| chr22:39,077,158–39,077,634 | 283.1 kb | Distal (>10kb) Multiome | 66 | |
| chr22:39,087,857–39,088,400 | 293.9 kb | Distal (>10kb) Multiome | 32 |
Genomic view of the DNAL4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.