This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on other chromosomes. [provided by RefSeq, Sep 2015]
Transcription factors with Perturb-seq knockdown data for DNAJA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DNAJA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DNAJA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:32,782,490–32,784,047 | 241.8 kb | Distal (>10kb) Multiome | 305 | |
| chr9:32,950,445–32,951,255 | 74.4 kb | Distal (>10kb) Multiome | 12 | |
| chr9:33,000,845–33,002,021 | 23.7 kb | Distal (>10kb) Multiome | 802 | |
| chr9:33,024,523–33,026,243 | 26 bp | At TSS Multiome | 972 | |
| chr9:33,044,108–33,044,981 | 19.3 kb | Distal (>10kb) Multiome | 451 | |
| chr9:33,076,221–33,076,965 | 51.5 kb | Distal (>10kb) Multiome | 804 | |
| chr9:33,166,320–33,168,338 | 142.1 kb | Distal (>10kb) Multiome | 849 | |
| chr9:33,171,750–33,173,178 | 147.3 kb | Distal (>10kb) Multiome | 359 | |
| chr9:33,264,068–33,265,475 | 239.5 kb | Distal (>10kb) Multiome | 790 | |
| chr9:33,267,199–33,267,770 | 242.2 kb | Distal (>10kb) Multiome | 106 | |
| chr9:33,290,056–33,291,152 | 265.2 kb | Distal (>10kb) Multiome | 1075 |
Genomic view of the DNAJA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.