This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DMAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DMAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DMAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:43,933,385–43,935,511 | 278.6 kb | Distal (>10kb) Multiome | 565 | |
| chr1:43,935,659–43,937,001 | 276.8 kb | Distal (>10kb) Multiome | 359 | |
| chr1:43,946,199–43,947,337 | 266.8 kb | Distal (>10kb) Multiome | 1003 | |
| chr1:43,969,717–43,970,284 | 243.6 kb | Distal (>10kb) Multiome | 515 | |
| chr1:43,974,246–43,975,571 | 238.6 kb | Distal (>10kb) Multiome | 875 | |
| chr1:43,978,661–43,979,381 | 234.4 kb | Distal (>10kb) Multiome | 419 | |
| chr1:43,991,242–43,992,448 | 221.6 kb | Distal (>10kb) Multiome | 780 | |
| chr1:44,000,140–44,000,654 | 213.0 kb | Distal (>10kb) Multiome | 43 | |
| chr1:44,029,597–44,032,070 | 181.8 kb | Distal (>10kb) Multiome | 896 | |
| chr1:44,036,004–44,036,357 | 177.3 kb | Distal (>10kb) Multiome | 452 | |
| chr1:44,134,442–44,134,897 | 78.8 kb | Distal (>10kb) Multiome | 32 | |
| chr1:44,213,251–44,213,777 | 4 bp | At TSS Multiome | 1062 | |
| chr1:44,217,794–44,218,185 | 4.3 kb | Proximal (<10kb) | 277 | |
| chr1:44,238,024–44,238,695 | 24.9 kb | Distal (>10kb) Multiome | 396 | |
| chr1:44,240,892–44,241,669 | 27.8 kb | Distal (>10kb) Multiome | 103 | |
| chr1:44,290,412–44,291,163 | 77.3 kb | Distal (>10kb) Multiome HiCAR | 270 | |
| chr1:44,316,195–44,316,964 | 103.0 kb | Distal (>10kb) Multiome HiCAR | 103 | |
| chr1:44,354,715–44,355,536 | 141.8 kb | Distal (>10kb) Multiome | 626 | |
| chr1:44,404,952–44,406,390 | 191.7 kb | Distal (>10kb) Multiome | 647 | |
| chr1:44,417,400–44,418,123 | 204.1 kb | Distal (>10kb) Multiome | 272 | |
| chr1:44,500,703–44,501,235 | 287.6 kb | Distal (>10kb) Multiome | 128 | |
| chr1:44,512,396–44,512,984 | 299.2 kb | Distal (>10kb) Multiome | 68 | |
| chr1:44,673,636–44,675,002 | 461.0 kb | Distal (>10kb) Multiome HiCAR | 750 |
Genomic view of the DMAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.