This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]
Transcription factors with Perturb-seq knockdown data for DLC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DLC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DLC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:12,951,067–12,952,574 | 181.5 kb | Distal (>10kb) Multiome | 496 | |
| chr8:12,972,190–12,973,116 | 160.7 kb | Distal (>10kb) Multiome | 182 | |
| chr8:13,041,246–13,042,612 | 91.7 kb | Distal (>10kb) Multiome HiCAR | 464 | |
| chr8:13,059,354–13,060,646 | 73.3 kb | Distal (>10kb) Multiome | 365 | |
| chr8:13,081,802–13,082,427 | 51.2 kb | Distal (>10kb) Multiome | 66 | |
| chr8:13,105,620–13,106,699 | 27.2 kb | Distal (>10kb) Multiome | 247 | |
| chr8:13,121,610–13,122,407 | 11.3 kb | Distal (>10kb) Multiome | 170 | |
| chr8:13,124,525–13,124,690 | 8.8 kb | Proximal (<10kb) | 11 | |
| chr8:13,127,586–13,127,955 | 5.5 kb | Proximal (<10kb) | 65 | |
| chr8:13,131,138–13,134,186 | 1.6 kb | Proximal (<10kb) Multiome | 823 | |
| chr8:13,275,776–13,277,286 | 143.4 kb | Distal (>10kb) Multiome | 823 | |
| chr8:13,278,561–13,278,797 | 2.0 kb | Proximal (<10kb) | 7 | |
| chr8:13,278,930–13,279,624 | 2.4 kb | Proximal (<10kb) | 10 | |
| chr8:13,566,181–13,567,169 | 433.5 kb | Distal (>10kb) Multiome | 304 |
Genomic view of the DLC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.