Predicted to enable GTPase activator activity. Involved in cell migration and positive regulation of Wnt signaling pathway. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DEPDC1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DEPDC1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DEPDC1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:60,699,432–60,700,719 | 52 bp | At TSS Multiome | 1005 | |
| chr5:60,797,358–60,798,212 | 97.8 kb | Distal (>10kb) Multiome | 104 | |
| chr5:60,842,894–60,844,886 | 144.2 kb | Distal (>10kb) Multiome | 755 | |
| chr5:60,854,444–60,855,160 | 154.6 kb | Distal (>10kb) Multiome | 164 | |
| chr5:60,944,760–60,946,207 | 245.1 kb | Distal (>10kb) Multiome HiCAR | 759 | |
| chr5:62,218,824–62,219,304 | 1518.9 kb | Distal (>10kb) Multiome HiCAR | 27 |
Genomic view of the DEPDC1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.