Enables aspartic-type endopeptidase activity; identical protein binding activity; and ubiquitin binding activity. Involved in several processes, including cellular response to hydroxyurea; proteolysis; and regulation of DNA stability. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DDI2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DDI2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DDI2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:15,409,150–15,410,227 | 207.7 kb | Distal (>10kb) Multiome | 618 | |
| chr1:15,412,068–15,412,674 | 205.1 kb | Distal (>10kb) Multiome | 120 | |
| chr1:15,523,864–15,525,570 | 92.8 kb | Distal (>10kb) Multiome | 674 | |
| chr1:15,526,118–15,527,442 | 90.7 kb | Distal (>10kb) Multiome | 899 | |
| chr1:15,584,405–15,585,197 | 32.7 kb | Distal (>10kb) Multiome | 693 | |
| chr1:15,603,163–15,603,936 | 13.8 kb | Distal (>10kb) Multiome | 795 | |
| chr1:15,616,785–15,618,260 | 102 bp | At TSS Multiome | 909 | |
| chr1:15,676,618–15,677,408 | 59.7 kb | Distal (>10kb) Multiome | 95 | |
| chr1:15,741,258–15,741,859 | 124.1 kb | Distal (>10kb) Multiome | 436 | |
| chr1:15,757,615–15,759,609 | 141.1 kb | Distal (>10kb) Multiome | 439 | |
| chr1:15,799,931–15,800,776 | 182.9 kb | Distal (>10kb) Multiome | 734 | |
| chr1:15,834,229–15,836,682 | 218.6 kb | Distal (>10kb) Multiome | 1154 | |
| chr1:15,847,036–15,848,900 | 230.2 kb | Distal (>10kb) Multiome | 817 | |
| chr1:15,849,314–15,850,241 | 232.2 kb | Distal (>10kb) Multiome | 788 |
Genomic view of the DDI2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.