This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DCHS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCHS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCHS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:6,367,341–6,367,799 | 288.3 kb | Distal (>10kb) Multiome | 55 | |
| chr11:6,389,605–6,390,990 | 265.5 kb | Distal (>10kb) Multiome | 752 | |
| chr11:6,405,086–6,405,670 | 250.4 kb | Distal (>10kb) Multiome | 99 | |
| chr11:6,418,399–6,419,618 | 236.7 kb | Distal (>10kb) Multiome | 494 | |
| chr11:6,468,896–6,469,642 | 186.6 kb | Distal (>10kb) Multiome | 253 | |
| chr11:6,473,129–6,474,612 | 181.8 kb | Distal (>10kb) Multiome | 591 | |
| chr11:6,480,885–6,482,114 | 174.4 kb | Distal (>10kb) Multiome | 828 | |
| chr11:6,496,967–6,497,550 | 158.5 kb | Distal (>10kb) Multiome | 71 | |
| chr11:6,586,489–6,587,591 | 68.8 kb | Distal (>10kb) Multiome | 231 | |
| chr11:6,603,192–6,604,726 | 52.1 kb | Distal (>10kb) Multiome | 908 | |
| chr11:6,606,600–6,607,433 | 48.7 kb | Distal (>10kb) Multiome | 532 | |
| chr11:6,611,505–6,613,097 | 43.5 kb | Distal (>10kb) Multiome | 996 | |
| chr11:6,618,753–6,619,738 | 36.4 kb | Distal (>10kb) Multiome | 587 | |
| chr11:6,629,672–6,631,067 | 25.3 kb | Distal (>10kb) Multiome | 226 | |
| chr11:6,655,068–6,656,298 | 44 bp | At TSS Multiome | 314 | |
| chr11:6,682,693–6,683,793 | 27.6 kb | Distal (>10kb) Multiome | 950 | |
| chr11:6,925,579–6,927,200 | 270.7 kb | Distal (>10kb) Multiome | 584 |
Genomic view of the DCHS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.