Enables dephospho-CoA kinase activity. Predicted to be involved in coenzyme A biosynthetic process. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DCAKD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DCAKD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DCAKD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:44,758,700–44,759,204 | 302.2 kb | Distal (>10kb) Multiome | 167 | |
| chr17:44,774,509–44,776,365 | 286.3 kb | Distal (>10kb) Multiome | 794 | |
| chr17:44,778,982–44,779,764 | 281.6 kb | Distal (>10kb) Multiome | 595 | |
| chr17:44,829,525–44,830,482 | 230.9 kb | Distal (>10kb) Multiome | 503 | |
| chr17:44,899,009–44,900,053 | 161.4 kb | Distal (>10kb) Multiome | 987 | |
| chr17:44,911,165–44,911,786 | 149.6 kb | Distal (>10kb) Multiome | 412 | |
| chr17:44,947,322–44,948,161 | 113.2 kb | Distal (>10kb) Multiome | 891 | |
| chr17:44,966,864–44,969,160 | 92.6 kb | Distal (>10kb) Multiome | 526 | |
| chr17:44,987,181–44,987,616 | 73.5 kb | Distal (>10kb) Multiome | 93 | |
| chr17:45,021,768–45,022,248 | 38.9 kb | Distal (>10kb) Multiome | 739 | |
| chr17:45,051,210–45,051,755 | 9.5 kb | Proximal (<10kb) Multiome | 771 | |
| chr17:45,060,587–45,061,694 | 207 bp | At TSS Multiome | 979 | |
| chr17:45,064,760–45,065,008 | 3.7 kb | Proximal (<10kb) | 49 | |
| chr17:45,131,590–45,133,655 | 72.4 kb | Distal (>10kb) Multiome | 898 | |
| chr17:45,135,189–45,136,052 | 74.5 kb | Distal (>10kb) Multiome | 930 | |
| chr17:45,143,207–45,145,183 | 82.8 kb | Distal (>10kb) Multiome | 308 | |
| chr17:45,147,066–45,150,271 | 86.4 kb | Distal (>10kb) Multiome | 1345 | |
| chr17:45,160,688–45,162,340 | 100.6 kb | Distal (>10kb) Multiome | 1200 | |
| chr17:45,197,493–45,198,189 | 136.9 kb | Distal (>10kb) Multiome | 835 | |
| chr17:45,241,380–45,242,217 | 180.8 kb | Distal (>10kb) Multiome | 131 | |
| chr17:45,246,828–45,248,615 | 186.8 kb | Distal (>10kb) Multiome | 858 | |
| chr17:45,261,690–45,262,406 | 201.0 kb | Distal (>10kb) Multiome | 234 | |
| chr17:45,316,202–45,317,910 | 256.2 kb | Distal (>10kb) Multiome | 857 | |
| chr17:45,334,174–45,334,847 | 273.4 kb | Distal (>10kb) Multiome | 149 |
Genomic view of the DCAKD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.