This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. Certain mutations in this gene are known to cause distinct forms of muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for DAG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DAG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DAG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:49,170,896–49,171,950 | 298.9 kb | Distal (>10kb) Multiome | 781 | |
| chr3:49,276,912–49,277,398 | 193.2 kb | Distal (>10kb) Multiome | 291 | |
| chr3:49,339,607–49,340,853 | 130.1 kb | Distal (>10kb) Multiome | 1044 | |
| chr3:49,357,868–49,359,083 | 111.8 kb | Distal (>10kb) Multiome | 908 | |
| chr3:49,411,409–49,412,844 | 58.1 kb | Distal (>10kb) Multiome | 899 | |
| chr3:49,422,179–49,422,905 | 47.7 kb | Distal (>10kb) Multiome | 453 | |
| chr3:49,428,857–49,429,869 | 40.8 kb | Distal (>10kb) Multiome | 712 | |
| chr3:49,461,484–49,462,134 | 8.5 kb | Proximal (<10kb) Multiome | 207 | |
| chr3:49,465,652–49,466,113 | 4.0 kb | Proximal (<10kb) | 339 | |
| chr3:49,468,926–49,470,930 | 59 bp | At TSS Multiome | 919 | |
| chr3:49,539,369–49,540,584 | 69.7 kb | Distal (>10kb) Multiome | 628 | |
| chr3:49,553,618–49,555,244 | 84.2 kb | Distal (>10kb) Multiome | 710 | |
| chr3:49,718,116–49,720,106 | 249.4 kb | Distal (>10kb) Multiome | 450 | |
| chr3:49,723,361–49,724,517 | 253.8 kb | Distal (>10kb) Multiome | 769 |
Genomic view of the DAG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.