Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Located in nucleoplasm. Part of U2-type precatalytic spliceosome and catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CWC27. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CWC27 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CWC27, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:64,505,514–64,507,841 | 262.5 kb | Distal (>10kb) Multiome | 447 | |
| chr5:64,690,060–64,691,616 | 78.2 kb | Distal (>10kb) Multiome | 408 | |
| chr5:64,705,728–64,706,826 | 62.7 kb | Distal (>10kb) Multiome | 254 | |
| chr5:64,744,765–64,745,704 | 23.8 kb | Distal (>10kb) Multiome | 169 | |
| chr5:64,760,120–64,760,918 | 8.4 kb | Proximal (<10kb) Multiome | 140 | |
| chr5:64,765,815–64,766,436 | 2.5 kb | Proximal (<10kb) | 84 | |
| chr5:64,767,999–64,769,372 | 182 bp | At TSS Multiome | 909 | |
| chr5:64,769,615–64,769,846 | 682 bp | At TSS | 28 | |
| chr5:64,770,235–64,770,535 | 1.3 kb | Proximal (<10kb) | 19 | |
| chr5:64,774,865–64,775,422 | 5.9 kb | Proximal (<10kb) | 35 | |
| chr5:65,033,655–65,036,380 | 266.7 kb | Distal (>10kb) Multiome | 966 | |
| chr5:65,102,224–65,103,650 | 334.3 kb | Distal (>10kb) Multiome | 507 | |
| chr5:65,481,460–65,482,620 | 712.9 kb | Distal (>10kb) Multiome HiCAR | 583 |
Genomic view of the CWC27 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.