Predicted to enable ubiquitin binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CUEDC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CUEDC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CUEDC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:57,612,112–57,613,173 | 279.8 kb | Distal (>10kb) Multiome | 230 | |
| chr17:57,662,590–57,663,471 | 229.6 kb | Distal (>10kb) Multiome | 392 | |
| chr17:57,750,076–57,750,566 | 142.4 kb | Distal (>10kb) Multiome | 85 | |
| chr17:57,756,756–57,757,413 | 135.6 kb | Distal (>10kb) Multiome | 131 | |
| chr17:57,783,050–57,783,717 | 109.2 kb | Distal (>10kb) Multiome | 468 | |
| chr17:57,833,107–57,833,593 | 59.4 kb | Distal (>10kb) Multiome | 406 | |
| chr17:57,849,786–57,850,720 | 42.5 kb | Distal (>10kb) Multiome | 1079 | |
| chr17:57,851,171–57,852,883 | 40.1 kb | Distal (>10kb) Multiome | 649 | |
| chr17:57,860,878–57,862,423 | 31.4 kb | Distal (>10kb) Multiome | 875 | |
| chr17:57,868,191–57,868,869 | 24.1 kb | Distal (>10kb) Multiome | 587 | |
| chr17:57,874,428–57,875,544 | 17.9 kb | Distal (>10kb) Multiome | 639 | |
| chr17:57,876,029–57,876,327 | 7.6 kb | Proximal (<10kb) | 98 | |
| chr17:57,892,543–57,893,376 | 78 bp | At TSS Multiome | 825 | |
| chr17:57,898,956–57,899,383 | 6.3 kb | Proximal (<10kb) | 231 | |
| chr17:57,901,269–57,901,796 | 8.9 kb | Proximal (<10kb) Multiome | 289 | |
| chr17:57,926,939–57,927,538 | 34.5 kb | Distal (>10kb) Multiome | 259 | |
| chr17:57,954,427–57,955,892 | 62.7 kb | Distal (>10kb) Multiome | 612 | |
| chr17:57,987,092–57,989,001 | 95.6 kb | Distal (>10kb) Multiome HiCAR | 1036 | |
| chr17:58,006,337–58,008,268 | 114.8 kb | Distal (>10kb) Multiome | 1147 | |
| chr17:58,082,555–58,084,952 | 190.6 kb | Distal (>10kb) Multiome HiCAR | 835 | |
| chr17:58,156,945–58,157,756 | 264.5 kb | Distal (>10kb) Multiome | 235 |
Genomic view of the CUEDC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.