This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Transcription factors with Perturb-seq knockdown data for CTDP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CTDP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CTDP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:79,393,688–79,395,560 | 285.6 kb | Distal (>10kb) Multiome | 539 | |
| chr18:79,395,691–79,396,909 | 283.9 kb | Distal (>10kb) Multiome | 372 | |
| chr18:79,399,259–79,400,995 | 279.4 kb | Distal (>10kb) Multiome | 361 | |
| chr18:79,506,395–79,507,651 | 172.8 kb | Distal (>10kb) Multiome | 390 | |
| chr18:79,567,133–79,567,644 | 112.5 kb | Distal (>10kb) Multiome | 54 | |
| chr18:79,600,813–79,601,925 | 78.4 kb | Distal (>10kb) Multiome | 253 | |
| chr18:79,610,922–79,611,725 | 68.6 kb | Distal (>10kb) Multiome | 353 | |
| chr18:79,678,750–79,680,983 | 431 bp | At TSS Multiome | 955 | |
| chr18:79,797,637–79,799,132 | 118.2 kb | Distal (>10kb) Multiome | 246 | |
| chr18:79,950,747–79,952,381 | 271.9 kb | Distal (>10kb) Multiome | 606 | |
| chr18:79,960,055–79,960,750 | 280.6 kb | Distal (>10kb) Multiome | 94 | |
| chr18:79,964,253–79,964,855 | 284.7 kb | Distal (>10kb) Multiome | 536 |
Genomic view of the CTDP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.