Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for CSE1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CSE1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CSE1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:48,751,156–48,751,799 | 294.9 kb | Distal (>10kb) Multiome | 254 | |
| chr20:48,825,950–48,828,654 | 220.0 kb | Distal (>10kb) Multiome | 682 | |
| chr20:48,846,443–48,846,926 | 199.7 kb | Distal (>10kb) Multiome | 257 | |
| chr20:48,858,252–48,858,759 | 187.8 kb | Distal (>10kb) Multiome | 100 | |
| chr20:48,921,125–48,922,305 | 124.6 kb | Distal (>10kb) Multiome | 1077 | |
| chr20:49,045,736–49,047,213 | 234 bp | At TSS Multiome | 1069 | |
| chr20:49,187,732–49,189,017 | 142.1 kb | Distal (>10kb) Multiome | 893 | |
| chr20:49,218,926–49,220,026 | 173.0 kb | Distal (>10kb) Multiome | 836 | |
| chr20:49,277,517–49,279,612 | 232.1 kb | Distal (>10kb) Multiome | 1199 | |
| chr20:49,289,765–49,291,410 | 244.0 kb | Distal (>10kb) Multiome | 436 |
Genomic view of the CSE1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.