This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CRABP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRABP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRABP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:78,077,036–78,077,991 | 262.8 kb | Distal (>10kb) Multiome | 552 | |
| chr15:78,130,851–78,132,005 | 208.8 kb | Distal (>10kb) Multiome | 769 | |
| chr15:78,148,893–78,150,142 | 191.0 kb | Distal (>10kb) Multiome | 746 | |
| chr15:78,264,436–78,265,112 | 75.6 kb | Distal (>10kb) Multiome | 241 | |
| chr15:78,299,130–78,299,874 | 40.7 kb | Distal (>10kb) Multiome | 798 | |
| chr15:78,303,744–78,304,214 | 36.5 kb | Distal (>10kb) Multiome | 287 | |
| chr15:78,331,404–78,331,679 | 8.7 kb | Proximal (<10kb) | 42 | |
| chr15:78,340,100–78,340,745 | 72 bp | At TSS Multiome | 194 | |
| chr15:78,340,988–78,341,655 | 636 bp | At TSS | 119 | |
| chr15:78,348,106–78,348,824 | 8.1 kb | Proximal (<10kb) Multiome | 178 | |
| chr15:78,437,554–78,438,897 | 97.8 kb | Distal (>10kb) Multiome | 918 | |
| chr15:78,506,965–78,508,087 | 167.1 kb | Distal (>10kb) Multiome | 674 | |
| chr15:78,539,941–78,541,020 | 200.2 kb | Distal (>10kb) Multiome | 773 | |
| chr15:78,564,790–78,566,388 | 225.1 kb | Distal (>10kb) Multiome | 618 | |
| chr15:78,619,950–78,621,461 | 279.8 kb | Distal (>10kb) Multiome | 274 |
Genomic view of the CRABP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.