This gene likely encodes a member of the carboxypeptidase family of proteins. Cloning of a comparable locus in mouse indicates that the encoded protein contains a discoidin domain and a carboxypeptidase domain, but the protein appears to lack residues necessary for carboxypeptidase activity.[provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for CPXM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CPXM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CPXM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:2,508,648–2,509,663 | 291.6 kb | Distal (>10kb) Multiome | 854 | |
| chr20:2,524,432–2,525,455 | 276.0 kb | Distal (>10kb) Multiome | 724 | |
| chr20:2,536,033–2,536,583 | 264.3 kb | Distal (>10kb) Multiome | 42 | |
| chr20:2,651,802–2,653,286 | 148.1 kb | Distal (>10kb) Multiome | 1060 | |
| chr20:2,663,925–2,664,409 | 136.4 kb | Distal (>10kb) Multiome | 908 | |
| chr20:2,692,159–2,694,013 | 108.0 kb | Distal (>10kb) Multiome | 584 | |
| chr20:2,752,636–2,753,047 | 47.9 kb | Distal (>10kb) Multiome | 395 | |
| chr20:2,798,928–2,799,196 | 1.4 kb | Proximal (<10kb) | 59 | |
| chr20:2,799,718–2,800,074 | 552 bp | At TSS | 111 | |
| chr20:2,800,326–2,801,021 | 97 bp | At TSS Multiome | 349 | |
| chr20:2,840,006–2,841,330 | 40.0 kb | Distal (>10kb) Multiome | 997 | |
| chr20:2,872,329–2,874,047 | 72.9 kb | Distal (>10kb) Multiome | 980 | |
| chr20:3,045,415–3,046,996 | 245.3 kb | Distal (>10kb) Multiome | 999 | |
| chr20:3,071,569–3,072,466 | 271.6 kb | Distal (>10kb) Multiome | 214 | |
| chr20:3,092,619–3,093,442 | 292.4 kb | Distal (>10kb) Multiome | 180 |
Genomic view of the CPXM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.